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HER-3 plays an important role in the growth, progression and development of drug resistance in several cancers. HER-3 is kinase impaired, therefore its inhibition can only be obtained through use of a neutralizing antibody.... more
Italian SME specialized in drug discovery and located in Central Italy has developed and patented an anti-TEM1 monoclonal antibody which has been used to generate a TEM1 targeting ADC. Compared with the naked... more
The product is in pre-clinical stage of development. In order to submit the application for phase 1 trial, the following steps have to be performed: (i) generation of a stable antibody producing... more
There have been many innovations in the treatment of cancer one of which has been the use of antibody-drug conjugates (ADCs) where antibodies that target markers on cancer cells are linked to chemotherapy drugs.... more
generation biologics based on its two patented transgenic mouse platforms for producing fully human antibodies.
Therapeutic monoclonal antibody (mAb) is one of the fastest growing segments of the global pharmaceutical... more
presence of antibodies in the atherosclerotic plaque was described decades ago, and the connection between autoimmunity and atherosclerosis is well accepted. However, the immunogenic trigger and the impact of the antibody... more
variations. The method identifies up to thousands of potential epitope/mimotope peptides combining even structural epitopes in single peptides to predict species specificity and fitness for usage. Only µg amounts of antibody... more
administration of a GD2-specific CAR-T cell or CAR-NK cell or a GD2 specific antibody to the subject. Further, the present invention relates to a GD2-specific CAR-T cell or CAR-NK cell or a GD2-specific more
innovative technology takes advantage of magnetic nanoparticles coated with a monoclonal antibody that are injected into the bloodstream via an intravenous cannula, as well as of a special wire containing a magnetic... more
), human cytomegalovirus (HCMV) and human (mostly) and mouse lymphocytes receptors and their ligands.
The database is a collection of monoclonal antibodies (mAbs). For most of the targeted proteins, there is no other antibody... more
effect with an anti—CD20 antibody. In addition, the combination of miRNA with low doses of CHOP is therapeutically efficient and allows decreasing CHOP therapeutic concentration and its toxicity, thus reducing... more
this technology is in terms of the cost compared to the high-cost norovirus concentration method which uses an expensive antibody.
Therefore, under commercial agreement with technical assistance and license... more
therapeutic purposes. In particular when coupled to a drug, the aptamer may be used in analogy to an antibody-drug-conjugate.
The offer addresses companies from the pharmaceutical or biotechnology sector that... more
could be an industry blockbuster. The platform enables the discovery and development of new biopharmaceuticals, enzymes and high production cell lines. The system will be fully-automated and can be integrated into various antibody... more
patented a technology that solves this problem. Their immunosensors contain reservoirs for storing antibody-decorated nanoparticles in the same filter paper. Folding the paper allows the easy transfer of reagents... more
biomolecule such as a protein, antibody, or amino acid.)
The developed sensor technology provides very specific properties due to its special geometry, which allows the transformation of the whole or of only... more
directed against its catalytic domain. They have studied some anti-MT4-MMP antibodies that showed to be specific, to bind to the native protein and to have MT4-MMP inhibitory activity. Finally, they selected the monoclonal antibody... more
materials throughout years of research and offers their expertise to potential partners for tailored applications.
(3) Bioanalysis (antibody-antigen interactions, etc.) and determination of pH, temperature, oxygen,... more
often based on nanoparticles or conjugation with antibodies; however, nanoparticle systems are often nonspecific and require high doses of drugs to be effective, and antibody-based systems are costly.
One of... more