Partnering opportunity

Micro fluidic system for simulating in vivo-equivalent cell barriers

Summary

A German university of applied sciences has developed a micro fluidic barrier system, which is simulating the native in vivo situation as it occurs at cell barriers, e.g. when separating the cell compartments in two different milieus such as intestinal lumen and blood. The university is looking for exclusive or non-exclusive licensing for developing, production and distribution of the technology in United Kingdom or France; option agreements and further technical cooperation are possible.

Partner sought

An industrial partner is looked for, which should have technical expertise in micro fluidic technologies and should be interested in licensing, producing and marketing the new technology. The role of the industrial partner is to identify the requirements of the market with the customer needs and to realise the corresponding further technical development, e.g. technical adaptions or functional extensions, manufacturing requirements etc. The university of applied science as a cooperation partner offers its expertise to carry out supporting studies.

Description

The German university is specialised in micro fluidic systems and carries out applied research in biological barrier systems. In vivo like models are very important in the field of pharma- and medical research. They provide the ability to analyse complex relations under defined conditions. To simulate such barrier systems it is suitable to imitate the native conditions as they occur at cell barriers in vivo. For this reason it is necessary to simulate in vivo cell barriers, which are accessible both from the apical and the basolateral side. Static systems such as standard cell cultures (“Transwells”) provide only limited means. The micro fluidic system is simulating the in vivo situation, where the cell barrier separates the compartments in two different milieus such as intestinal lumen and blood. The system comprises a container with one or more micro fluidic modules. Each module consists of two micro-structured polycarbonate (PC) sheets separated by a transmissible poly-carbonate membrane. With this technology the internalised intestinal mucous membrane can be simulated under in vivo-equivalent conditions. Thus, the micro-fluidic system allows the mono- and/or co-cultivation of cells under extended continuous media flow conditions. This system can be applied for the research on pharmaceutical compounds as well as preclinical tests. It is useful for simulating cell barriers like the blood-brain barrier or the lung mucosa as well as the intestinal mucosa. The system can be suitably used for testing the effects of biologically active substances or pharmaceuticals at cell barriers on both sides. The university seeks to out-license the new technology to companies capable to further develop the technology towards a marketable product and to production. With the functional prototype as a starting point the university is ready to support technical development by a technical cooperation agreement or subcontracting.

Advantages and innovations

• The system resembles the in vivo situation of cell barriers. • The cell barrier is accessible both from the apical and the basolateral side. • Different cell types can be cultured on both sides of the polycarbonate- membrane.

Development stage

Prototype available for demonstration

Intellectual Property Rights (IPR)

Patents granted


Register your interest

How it works

  • Tell us about yourself
  • We’ll discuss with you
  • We put the right partners in touch

EEN help you find the right partner, rather than you going it alone.

Our role is to review and collate the most suitable submissions, and then send them to the client who posted the opportunity. We consult with you, and the client, to make the process professional and easy.

These are live opportunities. Your registration of interest on the site is just like a professional approach to a business at a networking event. To stand the best chance of success, make your submission really sing. Sell why the client who posted the opportunity should work with you. Excite them. Ask questions. Try and avoid copy and pasting words from elsewhere.

Once the client has chosen their partner, we'll introduce them over email and keep in touch with both parties to see how it's going. Sometimes things progress quickly. Sometimes because of changing priorities for either party, things progress slowly, but you never know - your next big business break could start right here.

?What value does EEN add?
This is your pitch: remember to include your unique selling points (USP) and why someone would want to do business with you
Tell us why you are a good fit for this opportunity, and why you think you're the right people for this partnership
If there's anything additional, or commercially sensitive you'd like to know about this opportunity, please let us know

When you entered your email address above, we emailed you a code to verify you're human and have access to that account.

?What's this?

What next?

To finish up, we just need some extra details about you and your company