Partnering opportunity

Graphene transistor system for measuring electrophysiological signals

Summary

A Spanish biomedical research networking center has developed an innovative flexible and versatile graphene-transistor array for measuring electrophysiological signals in biological systems such as brain, heart, kidneys, stomach, cranial nerves, and other regions, looking to establish a license, research cooperation or technical cooperation agreements.

Partner sought

Patent ready for licensing-out We are seeking industrial partners, either Biotech or Medtech, to: - enter into R&D collaboration via research cooperation agreement (further development of the medical device) - Further development until clinical proof-of-concept through license agreement or technical cooperation agreement.

Description

This research networking center gathers some of the main Spanish research groups in biomedicine, located in more than 100 institutions as universities, hospitals and technological centers distributed around the country. Brain-computer interfaces and neural prostheses based on the detection of electrocorticography signals are rapidly growing fields of research. Several technologies are currently competing to be the first to reach the market; however, none of them fulfill yet all the requirements of the ideal interface with neurons. Thanks to its biocompatibility, low dimensionality, mechanical flexibility, and electronic properties, graphene is one of the most promising material candidates for neural interfacing. In this context, solution-gated field effect transistors (SGFETs) with the use of graphene as the conductive channel (gSGFETs) hold tremendous promise in biomedical applications due to the excellent properties in biocompatibility inherent in graphene, as well as extremely high mobility. Considering that gSGFETs combine flexibility, even stretchability if built in a proper design, biocompatibility, and excellent neural recording performance, it is believed that gSGFETs represent a very powerful technology that can help to advance the current knowledge and technology boundaries of in vivo neural electrophysiology. The research center is looking to establish a license, research cooperation or technical cooperation agreements with medical devices and biotech companies for proof of concepts and license agreements for exploitation of their technology.

Advantages and innovations

The device has been mainly tested in brain signals (neural disorders) but it can be also applied to other biological systems such as heart, kidneys, stomach, cranial nerves, and other regions. This new graphene solution-gated field-effect transistor arrays (gSGFETs) are able to record infraslow signals alongside with signals in the typical local field potential bandwidth. This device increases baseline stability that arises from the electrochemical inertness of graphene. Transistors can be scaled up from micro to macro scale as needed while different kinds of electrical contacts. The gSGFETs are preferably placed on epicortical and intracortical positions. The gSGFETs are fabricated using a flexible substrate to overcome the difficulty in conforming to the geometry of different biological structures. Graphene-transistor arrays allow several applications and deployments which range from subdural, epidural and intracortical devices to other placements in the brain, peripheral and cranial nerves, heart, blood vessels, spinal cord, and other biological structures or non-invasive placement similar to an electroencephalogram.

Development stage

Under development/lab tested

Intellectual Property Rights (IPR)

Patent(s) applied for but not yet granted


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