Therapeutic targets in chemokine receptors to select useful compounds for pathologies treatment that intervene in chemokine responses
A Spanish public research institution has identified a molecular target in the transmembrane VI region of the chemokine receptors, specifically in CXCR4, that is used to design and detect selective compounds that modulate/antagonize chemokine-mediated function by altering receptor oligomerisation, in contrast to classical strategies based on ligand binding blockade. Industrial partners from the pharmaceutical industry are being sought to collaborate through a patent license agreement.
Industrial partners from the pharmaceutical industry are being sought to collaborate through a patent licence agreement.
The residues responsible for chemokine-mediated receptor oligomerization are a therapeutic target that can be exogenously modulated in order to treat cancer metastasis, inflammatory and autoimmune diseases or HIV-1 infection. The specific sequence within the amino acid sequence of the CXCR4 is directly involved in receptor oligomerization, being thus a promising therapeutic target to intervene in chemokine-mediated responses within cells. All the technology required for the screening of small compounds acting on this target, both in vitro and in vivo, is available at the CNB lab.
Advantages and innovations
The invention falls within the fields of medicine and pharmacology, particularly within the field of therapeutic targets for the screening of compounds useful in the treatment of diseases or clinical conditions which symptoms or pathology are a consequence of the events triggered by chemokine signaling, such as inflammatory and autoimmune diseases, as well as cancer or HIV-1 infection. The invention relates to the identification of molecular targets in chemokine receptors/chemokine complexes whose modulation is crucial to intervene in specific chemokine-mediated cell responses without altering others. The exogenous modulation of these therapeutic targets would allow to specifically block some of the events triggered by the ligand to its receptor without affect ligand binding. The invention has been tested in in vivo experiments using a murine model for neutrophils homing to the bone marrow. The new target represents a completely new and effective approach to antagonize chemokine responses, opposed to the classical strategies based on ligand binding blockade that have always failed to obtain valuable drugs for clinical purposes.
Intellectual Property Rights (IPR)
Patent(s) applied for but not yet granted
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