Partnering opportunity

Protein nano- or microparticles as artificial inclusion bodies for drug delivery

Summary

A Spanish biomedical research networking center has developed a new drug-delivery system comprising protein microparticles that mimic the protein release features of IBs (inclusion bodies) and the human hormone secretory system. It will be used for the treatment of cancer, and any other pathology requiring intracellular or extracellular protein delivery, looking to establish license, research cooperation or joint venture agreements.

Partner sought

Seeking industrial partners, either Biotech or Pharma, to: • Industry for further development and/or license via license agreement. • Research organization for collaborative and innovation projects via research cooperation agreement. • Investor for financial support and/or setting-up of spin-off company via joint venture agreement.

Description

This research networking center gathers some of the main Spanish research groups in biomedicine, located in more than 100 institutions as universities, hospitals, and technological centers distributed around the country. Bacterial inclusion bodies (IBs) are mechanically stable, insoluble, discrete, and particulate proteinaceous materials produced in recombinant bacteria, with particle sizes ranging from 50 to 1500 nm, and with shapes including cylindrical, amorphous, spherical or ellipsoid. They contain one or few functional protein species (together with other possible components) that can be released intracellularly or extracellularly under physiological conditions, mimicking the functioning of the hormone-releasing human endocrine system. IBs are mechanically stable functional materials that are non-toxic when exposed to cells or to living beings, through oral administration or injection. Because of the combination of mechanical stability and functionality, IBs are then explored as self-immobilized catalysts, showing promises in biotechnological industries and applications. As catalysts, IBs do not pose any regulatory issues and are highly convenient. However, the clinical applicability of IBs is not exempt of drawbacks. They contain irremovable bacterial components at variable composition incompatible with a drug formulation. Moreover, due to the cell factory base, IBs carry on with several homogeneity issues between manufacturing batches. For all these reasons, the provision of alternative structures for delivering proteins of clinical value (hormones, enzymes, etc.) in cells or organs are needed, but the maintenance of the beneficial features of IBs is also desired. In particular, their high penetration to cells, the mechanic stability, and the depot/protein release functions. This new drug-delivery system comprises protein microparticles that mimic the protein release features of IBs (inclusion bodies) and the human hormone secretory system and can be used for the treatment of cancer, and any other pathology requiring intracellular or extracellular protein delivery. These innovative artificial IBs have a slow-release profile of any embedded protein at physiological conditions. The artificial IBs have been prepared in vitro (cell-free engineered) without the presence of bacterial cells, thus in a fully synthetic mode. This protein nano- or microparticles penetrate into cells, thus they can be used as a protein delivery system. The Spanish research center is looking to establish license, research cooperation, or joint venture agreements with industrial partners from the biotech or pharma sector.

Advantages and innovations

First protein microparticles resembling natural IBs, and avoiding the problematic features existing in natural IBs. They can be used as actives in pharmaceutical compositions for example, for treatment of cancer, and any other pathology requiring intracellular or extracellular protein delivery. They can be used for oral and transdermal or transmucosal delivery, and as subcutaneous implants. Also, they can be used as actives in cosmetic compositions.

Development stage

Under development/lab tested

Intellectual Property Rights (IPR)

Patent(s) applied for but not yet granted


Register your interest

How it works

  • Tell us about yourself
  • We’ll discuss with you
  • We put the right partners in touch

EEN help you find the right partner, rather than you going it alone.

Our role is to review and collate the most suitable submissions, and then send them to the client who posted the opportunity. We consult with you, and the client, to make the process professional and easy.

These are live opportunities. Your registration of interest on the site is just like a professional approach to a business at a networking event. To stand the best chance of success, make your submission really sing. Sell why the client who posted the opportunity should work with you. Excite them. Ask questions. Try and avoid copy and pasting words from elsewhere.

Once the client has chosen their partner, we'll introduce them over email and keep in touch with both parties to see how it's going. Sometimes things progress quickly. Sometimes because of changing priorities for either party, things progress slowly, but you never know - your next big business break could start right here.

?What value does EEN add?
This is your pitch: remember to include your unique selling points (USP) and why someone would want to do business with you
Tell us why you are a good fit for this opportunity, and why you think you're the right people for this partnership
If there's anything additional, or commercially sensitive you'd like to know about this opportunity, please let us know

When you entered your email address above, we emailed you a code to verify you're human and have access to that account.

?What's this?

What next?

To finish up, we just need some extra details about you and your company